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122,146,147 Overall, different E3 ubiquitin ligases function in ERAD processing, from protein translocation to protein degradation, exemplified by the selective association of the ATPase p97/VCP with E3 ubiquitin ligases
& Choi, Y
In aged mice, FOXO4-DRI treatment restored fur density, improved renal function, and increased physical activity levels, demonstrating functional rejuvenation through targeted senescent cell clearance
Recent advances in Nrf2 activators, such as synthetic triterpenoids and natural compounds, highlight the need for temporal precisionactivating Nrf2 early to preserve -cell function but avoiding chronic overexpression, which may promote cancer (Mohamadi et al., 2023)
The amphiphilic property of the selenium-platinum coordination molecules facilitates their assembly into nanoparticles and prolongs the circulation time of the drug in the bloodstream, which is important for in vivo drug delivery
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