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These devices represent a leap forward from the traditional syringe-and-needle approach, providing a less invasive method of drug delivery

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10.1152/ajplung.00300.2002

As with other gastrointestinal effects, constipation was more common during the dose escalation period and tended to decrease over time for many patients

Comment: A commenter recommended that CMS implement a 1 to 2-year upside-only participation option in ASM for small and independent practices, noting that this would allow them to build infrastructure and reporting capacity before being held financially liable for potential negative ASM payment adjustments