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If you find that side effects are interfering with your daily life, your provider can help you adjust your dosage or provide additional support

Patients should contact their provider if leg cramps are severe, persistent, or accompanied by swelling, weakness, or dark urinesymptoms suggesting rhabdomyolysis or serious muscle injury

This is the dose used in the STEP clinical trials and the FDA-approved dose for chronic weight management

The flip side is that the long half-life also creates relatively stable medication levels between doses, which can actually reduce side effect intensity compared to medications with more dramatic peaks and troughs