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GABA tone regulation and its cognitive functions in the brain

Ann Neurol (2006) 59:3948.10.1002/ana.20746 100 Garcia-CazorlaAQuadrosEVNascimentoAGarcia-SilvaMTBrionesPMontoyaJet alMitochondrial diseases associated with cerebral folate deficiency

The main disadvantage is the relatively low sensitivity making this parameter unsuitable as a screening tool

Glutathione (Reduced) Reduced glutathione is involved in the synthesis and repair of DNA, and enhances the antioxidant activity of vitamin C, the transport of amino acids, and the detoxification of harmful compounds

Furthermore, mitochondrial dysfunction in neurons may contribute to central energy depletion, which may impair synaptic plasticity and induce cognitive deficits and brain fatigue