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S.Bajwa-JosephM.LetchfordD.ChowdhuryK.et al (2017)

Pharmacovigilance refinement using MedDRA + Re-run disproportionality analyses with (a) Standardised MedDRA Queries where applicable, (b) stratification by reporter type (healthcare professional vs consumer), co-medication filters (exclude SGLT2), and time-to-onset modelling to separate early dehydration-linked symptoms from later endocrine/tissue changes

At the same dose, a 74 kg participant had about 1.4 times the exposure of a 110 kg reference, while a 143 kg participant had about 0.8 times. Weight alone does not set the dose, but it helps explain why the trial mean transfers poorly to bodies outside the studied range

By the end of this guide, you will have a clear understanding of how to incorporate these two powerhouses into your daily routine effectively

It also plays a significant role in maintaining strong bones