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A common functional polymorphism at codons 108 and 158 in the genes coding for SCOMT and MBCOMT (COMT Val 108/158 Met), respectively, has been examined in relationship to a number of neurological disorders involving the noradrenergic or dopaminergic systems, such as schizophrenia (Park et al., 2002) or Parkinson's disease (Kunugi et al., 1997)

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352 Furthermore, TCAs can also block muscarinic acetylcholine receptors, exerting anticholinergic effects and resulting in side effects such as dry mouth and constipation

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Diaz A, Rangel P, Montes de Oca Y, Lledas F, Hansberg W (2001)