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Histone acetyltransferases (HATs) and histone deacetylases (HDACs) can significantly influence critical physiological processes including development, metabolic homeostasis, immune function, inflammatory responses, oxidative stress, and autophagy by regulating gene expression, cell proliferation and differentiation, and cell survival, thereby influencing the initiation and progression of kidney diseases (Liu Y

Although HEK-293 cells do not fully recapitulate the phenotype of proximal tubule epithelium, they remain the most commonly used kidney cell model in MNPs studies

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Finally, ultrathin sections were cut, and the morphological changes of mitochondria were examined under the TEM (HT7800, Hitachi, Japan)

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