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doi: 10.1210/endo.135.5.7956929

Clinical Trial Data on Semaglutide Safety and Musculoskeletal Outcomes The SUSTAIN and SELECT trials, which enrolled over 10,000 patients on semaglutide, documented gastrointestinal adverse events in roughly 40% of participants but reported musculoskeletal complaints at rates consistent with placebo groups

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Which leads to an obvious question why not just pursue major dietary change and regular exercise in the first place