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It is present in all mammals and primarily synthesized within the liver to be stored in the cytosol and organelles of animal cells

10.1152/physiologyonline.2002.17.1.27 Physiology 78 HeY.YaoY.TsirkaS

Daniel Drucker, a professor at the University of Toronto Faculty of Medicine in Canada and a former adviser to Eli Lilly, said, "It shows the most powerful weight-loss effect among GLP-1 drugs developed so far" and evaluated it as "an effect on par with bariatric surgery (metabolic surgery for obesity)." He added, "If approved, most patients who need substantial weight reduction will choose retatrutide."

Vitamin B12, also known as cobalamine, is an essential water-soluble vitamin

Renal protective effects have emerged as another important extra-hepatic benefit [15]