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P., Yardley, J., Brown, C., Sigal, R

doi: 10.1177/030006057600400510

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Future research should aim to further elucidate the various subtypes of cellular senescence, including differences between stress-induced senescence, oncogene-induced senescence, and developmental senescence, as each may present unique therapeutic opportunities

Further medicinal chemistry optimization to improve structure activity relationship and potency as well as safety and toxicity, pharmacokinetic (bioavailability, half-life and biodistribution) and rodent in vivo studies will follow to determine the compounds potential to become suitable candidates for further development