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Therapeutic strategies include prokinetic agents, dietary modifications, and interventions targeting the gut microbiota, aiming to restore normal gastrointestinal function and alleviate symptoms

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Recent studies have demonstrated that p53 contributes to iron homeostasis by transcriptionally regulating the expression of solute carrier family 25 member 28 (SLC25A28) and ferredoxin reductase (FDXR) to enhance the susceptibility of cells to ferroptosis [127, 128]

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