### Semaglutide Mechanism of Action Semaglutide achieves **weight loss** through multiple complementary pathways: - **Central appetite suppression** acts on hypothalamic GLP-1 receptors to reduce hunger and increase satiety - **Delayed gastric emptying** slows stomach emptying, prolonging feelings of fullness - **Improved insulin sensitivity** reduces insulin resistance and promotes healthy glucose metabolism - **Reward pathway modulation** reduces cravings and food-seeking behavior by acting on mesolimbic dopamine circuits - **Potential direct effects on adipose tissue** emerging research suggests GLP-1 may directly influence fat metabolism For a complete breakdown of semaglutide's dosing protocol, see our [semaglutide dosing schedule week-by-week guide](/guides/semaglutide-dosing-schedule-week-by-week-guide)
Lipid Accumulation Researchers reported reduced lipid accumulation during selected adipocyte-differentiation and lipogenesis experiments
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Key highlights Tirzepatide (also known by FDA-approved brand names Mounjaro and Zepbound) is a dual receptor agonist (GLP-1/GIP) that helps reduce appetite, control blood sugar, and promote greater weight loss than single receptor GLP-1 receptor agonists, such as semaglutide
