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3 Studies in animal models have reported an increased requirement for cysteine in sepsis, probably due to an increased turnover of GSH, as GSH synthesis accounts for 40% of the increased cysteine utilization

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These were induced with permanent major vessel occlusions, central [38,39] and peripheral [40,41,42,43,44,45,46], similar noxious procedures [47,48,49,50], and agents applications [51,52,53,54,55,56]

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36 Alterations of immune mediators in the central and periphery In the brains of ASD patients, the numbers and activation of reactive microglia and astrocytes are increased in multiple brain regions