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Patients with certain thyroid cancer risks, particularly a personal or family history of medullary thyroid carcinoma or MEN2 syndrome are generally advised not to take these medications

For a broader class-level safety view, see the PepPal peptide side effects guide

continuous combined regimens use daily micronized progesterone 100 mg to mitigate endometrial-hyperplasia risk, with annual ultrasonography or biopsy for abnormal bleeding