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Creatine supplementation is associated with intracellular water retention in muscle tissue

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In the pilot IVF pretreatment trial by Salamun et al., metformin plus low-dose liraglutide yielded higher clinical pregnancy rates per embryo transfer and higher 12-months cumulative pregnancy rates despite similar weight loss between groups

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The central challenge lies in precisely determining whether to inhibit or activate autophagic pathways, a decision that depends on the specific molecular context, including the driver mutation and the resistance mechanism at play

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