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It mimics the action of a hormone called glucagon-like peptide-1 (GLP-1), which is involved in regulating appetite and glucose metabolism

Also, because GLP-1 drugs engage the brains reward circuitry the same system that governs not just craving but everyday motivation prolonged use could, in theory, dampen motivational drive in some people

This can drive overeating, weight gain, and poor metabolic health over time

One of the most clinically significant considerations when combining prednisolone and Wegovy relates to glucose metabolism and diabetes risk

[DOI] [PMC free article] [PubMed] [Google Scholar] 352.Suzuki Y., Hattori K., Hamanaka J., Murase T., Egashira Y., Mishiro K., Ishiguro M., Tsuruma K., Hirose Y., Tanaka H., et al