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In summary, alterations at the glutathione activator site result in an absent geometric and electrostatic complementary 3,50 for the reducing agent, explaining the inefficient reduction of numerous glutaredoxins 12,25,26,27,28,29,48 and thioredoxins by GSH

For a fuller explanation of the compound itself, see Understanding How Glutathione Works in Our Body

However, it has been found that derivatives of biguanide, Q48, and Q54, are two novel CLIC1 blockers that have higher anti-proliferative efficacy than metformin in vitro glioma stem cell 2D cultures and 3D spheres (99)

doi: 10.1016/S0378-8741(99)00054-9

Is it real or just a placebo effect