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Discussion Due to the central roles exerted by the three metabolically related peptide hormone receptors (GIPR, GLP-1R and GCGR) in the management of T2DM and obesity, the concept of combinatorial agonism or polypharmacology to synergize metabolic actions and maximize therapeutic benefits has been explored in the past decade with remarkable preclinical and clinical achievements

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This distinction arises from semaglutides selective promotion of secreting insulin when blood glucose levels rise, avoiding the potential dangers of excess insulin that can induce critically low levels of blood sugar

Experts say one problem is that temporary use could undermine health by diminishing lean muscle mass, every time a person resumes GLP-1s

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