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However, regardless of the positive effect of vitamin C on healthy melanocytes, in the case of neoplastic transformed cells, vitamin C at physiological levels promotes the development and metastasis of melanoma 176

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101 Despite major advances in the acknowledgment of tissue-specific NAD + homeostasis, further work will be needed to fully characterize the subcellular and systemic modulation of NAD + metabolism, which can improve the preventive and therapeutic strategies based on maintaining healthy NAD + homeostasis

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