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Misfolded mHTT forms intracellular aggregates, disrupts cellular homeostasis, and triggers widespread neuronal dysfunction

In a randomized, controlled crossover feeding trial, 60% of women with endometriosis and gastrointestinal complaints responded to a low FODMAP diet compared to 26% on a control diet, with significant improvements in abdominal pain, bloating, stool form, and disease-related quality of life after four weeks ( p 23 kg/m, and supplement durations longer than eight weeks [194]

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Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans