Preclinical Models of Cocaine and Psychostimulant Use Disorders Cocaine and related psychostimulants such as amphetamines exert their addictive potential primarily via enhanced dopaminergic signaling in mesolimbic circuits, particularly through increased dopamine availability in the NAc
Growth hormone pathways interact with insulin sensitivity and glucose metabolism areas that retatrutide also directly modulates creating a theoretical risk of unpredictable glycaemic effects, including both hypoglycaemia and hyperglycaemia
Journal reference: Valencia-Rincn, E., Rai, R., Chandra, V., & Wellberg, E
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Rarely, dexamfetamine or methylphenidate has been used to counteract this effect