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11 Research in rodents and humans has substantiated that GLP-1 receptor agonists have shown promising results in reducing alcohol consumption and preference through neurobiological impact on the mesolimbic reward pathways in the VTA and NAc by modulating neurotransmitters involved in addiction such as dopamine and glutamine

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Furthermore, it is important to recognise that the predicted absolute benefit of an intervention is dependent on the absolute risk and thus those with prior CVD events are more likely to experience a benefit over intermediate time frames than those with cardiovascular risk factors only