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Researchers have found that reducing the Tlr4 gene expression in mice significantly reduces cell death in the pancreas in a mouse model of pancreatitis.[ref] TLR4 is found at higher levels in people with acute pancreatitis, compared to healthy people.[ref] Genetic variants that increase TLR4 are associated with increased susceptibility to pancreatitis (see genotype report)

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That's according to a recent survey from Evercore ISI that focused on GLP-1s, which include Novo Nordisk's weight loss injection Wegovy and diabetes counterpart Ozempic

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