Both medications help regulate appetite and blood sugar levels, but they work slightly differently
Jean Readdy, a retired teacher living in Sinking Spring, Pennsylvania, is among the one in eight Americans who have tried a GLP-1 drug for weight loss or diabetes, more commonly known by brand names like Ozempic and Wegovy
Patients today have more effective weight-loss options than ever before, so this is a logical extension of our work, she said
Participants randomized to retatrutide initiated treatment with 2 mg once weekly and increased the dose in a step-wise approach every four weeks until reaching the target dose of 9 mg (via steps at 2 mg, 4 mg and 6 mg) or 12 mg (via steps at 2 mg, 4 mg, 6 mg and 9 mg)
Moreover, the GLP-1R knockout mice self-administered more nicotine than their wildtype counterparts (Tuesta et al., 2012)