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reduces epithelial barrier function in a myosin light chain kinase-dependent fashion

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This enzymatic defect reduces synthesis of glutathione and the resulting low intracellular glutathione levels remove the normal tonic inhibition of the enzyme -glutamylcysteine synthetase (Figure 1 and Figure 2, reaction 4)

Certification under this program indicates alignment with standards of sport drug-testing authorities such as WADA, NFL, MLB, NHL, MLS, NBA, PGA, LPGA, NCAA, NASCAR, ATP, WTA, CFL, UFC, and CrossFit