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DAMPs usually activate the innate immune response and macrophages are recruited and activated to secrete various mediators such as macrophage inhibitory protein-1, monocyte chemoattractant protein-1, and IL-8, leading to interstitial inflammation in the kidney [108]

For disaccharide glycosides, the first step involves the release of the terminal sugar via an arabinofuranosidase, rhamnopyranosidase, or apiofuranosidase, followed by -glucosidase cleavage releasing the terpenoid (Gunata et al

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It is notable that in the cryo-EM conditions here, ipratropium did not induce occlusion like with the native substrate carnitine