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Can occur with Synjardy: few unique serious side effects Can occur with Invokamet: bone fractures lower limb amputations Can occur with both Synjardy and Invokamet: severe allergic reaction Fourniers gangrene (severe infection near your genitals) increased low-density lipoprotein (LDL) cholesterol level hypoglycemia (low blood sugar level) ketoacidosis (a buildup of ketones, which causes your blood to become too acidic) lactic acidosis (increased acid level in your blood) serious UTIs, including pyelonephritis (infection that affects your kidneys) and urosepsis (infection that affects your bloodstream) low level of fluid in the body Effectiveness These drugs havent been directly compared in clinical studies

Drug Targets 13 , 285293 (2012)

Here, the probability of replicating either exceeds the probability of dying - leading to exponential growth - or remains smaller than the probability of dying - leading to extinction

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application

In a large study, Gao et al