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While its CNS entry may be limited after systemic delivery, its ability to exert central effectsespecially under specific delivery conditionsshould not be dismissed

Scientific evidence[14,15] of the critical role of serotonin in the pathogenesis of depression was instrumental to the development of some of the current antidepressant drugs (fluoxetine and sertraline [SERT]) that selectively inhibit the reuptake of serotonin at serotonin transporters, and thereby increase serotonin concentration within the synaptic cleft[15,16]

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