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Strategies to correct the incretin defects in patients with type 2 diabetes include replacement of GLP-1 with a long-acting analog that resists degradation and development of drugs that inhibit the enzyme DPP-4, which breaks down GLP-1

This impracticality is why pharmaceutical companies developed semaglutide and tirzepatide, which are chemically modified to last for days and absorb effectively through either injection or oral routes

When you eat too little, your body downregulates metabolism and increases hunger signals setting you up for overeating later

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Response Surface Methodology and its application in evaluating scientific activity