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No data to support stopping GLP-1 agonists prior to elective endoscopy: AGA multisociety statement

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dpp-4_inhibitors DPP-4 Inhibitors Sitagliptin Trade Name: Januvia Drug Class: oral hypoglycemics Mechanism of Action: An inhibitor of dipeptidyl peptidase-4 (DPP-4), a protease that degrades the incretin GLP-1 Incretins are hormones released from the GI tract in response to nutrient ingestion Incretins potentiate glucose-stimulated insulin secretion from beta cells in the pancreas As a result of inhibiting DPP-4, increased or prolonged GLP-1 levels are able to potentiate the secretion of insulin by the pancreas The effect produced by DPP-4 inhibitors is dependent on endogenous GLP-1 levels, and produce a modest effect on GLP-1 activity compared to giving GLP-1 receptor agonists (hence DPP-4 inhibitors do not have the same impact to produce weight loss as GLP-1 agonists)

Appearance: White crystalline powder Odor and taste: Almost odorless, sour taste Arsenic (As): 2 ppm Assay: 98.0 % Heavy Metals: 10 ppm Identification (IR): Corresponds Identification (Lead Acetate): Positive Identification (Ninhydrin): Positive Iron (Fe): 10 ppm Loss on Drying: 0.5 % Melting Point: About 185 o C Optical Rotation: -21 - -11 o Residue on Ignition: 0.1 % Solubility: Soluble in water Solution: Clear solution BSE/TSE Free: BSE/TSE Free Country of Origin: Report G22010 Revision#2 SDS_23.pdf Download Certificate of Analysis Product Recommendations List Price $ 41 .45 Price $ 39 .95 You Save $ 1 .50 List Price $ 41 .45 Price $ 39 .95 You Save $ 1 .50 List Price $ 41 .45 Price $ 39 .95 You Save $ 1 .50 List Price $ 41 .45 Price $ 39 .95 You Save $ 1 .50 List Price $ 41 .45 Price $ 39 .95 You Save $ 1 .50 List Price $ 237 .50 Price $ 225 .75 You Save $ 11 .75 List Price $ 237 .50 Price $ 225 .75 You Save $ 11 .75 List Price $ 1427 .55 Price $ 1360 .00 You Save $ 67 .55 List Price $ 68 .40 Price $ 66 .99 You Save $ 1 .41 List Price $ 75 .50 Price $ 70 .99 You Save $ 4 .51