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Mean change in body weight from baseline to Week 52 was a secondary endpoint.* Statistically significant vs Januvia 100 mg PIONEER 3 study design 1,4 In a double-blind, double-dummy trial with a primary endpoint of mean change in A1C from baseline to 26 weeks, 1864 adult patients with type 2 diabetes on metformin alone or metformin with a sulfonylurea were randomized to RYBELSUS 3 mg (n=466), RYBELSUS 7 mg (n=465), RYBELSUS 14 mg (n=465), or Januvia 100 mg (n=467), all once daily
10.1111/j.1365-2982.2007.01079.x 21 HellstrmP
It slows down how fast the stomach empties food
Ligand-induced internalization of TNF receptor 2 mediated by a di-leucin motif is dispensable for activation of the NFB pathway
Characterization of the CD177 interaction with the ANCA antigen proteinase 3
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