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In a smaller cohort of patients with more severe CD phenotypes, including 17% with perianal involvement and 24% with penetrating or fistulizing disease, numerical reductions across outcomes were observed in the GLP-1RA group, but these differences did not reach statistical significance (104)

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Patients should be counseled about the risk of dehydration and potential acute kidney injury with severe gastrointestinal symptoms, and the need to temporarily hold medication and seek care if severe vomiting or diarrhea occurs