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[32] [33] The NICE guidelines for obesity management emphasise the importance of comprehensive lifestyle interventions alongside pharmacological treatment, including adequate nutrition and physical activity, which indirectly support bone health

The most commonly reported side effects were gastrointestinal, including nausea, vomiting, diarrhea, stomach (abdominal) pain, and constipation

This initial phase typically lasts for four weeks, proceeding cautiously to ensure the medication is well-tolerated while beginning to impact appetite control and blood sugar levels positively

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Some people report weight loss, but there is limited clinical evidence to support microdosing as an effective long-term weight management strategy