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The well-studied large phi (GSTF) and tau (GSTU) classes are specific to plants whereas the small zeta (GSTZ) and theta (GSTT) classes exist also in animal tissues (Dixon et al., 1998, 2002)

Furthermore, the role of IGF-1 in attenuating hepatocyte premature senescence mediated by progerin needs further exploration

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Finally, in 1991 Burger widened the definition of bioisosteres to include compounds or groups that possess similar molecular shapes and volumes independent of agonists or antagonists [7]

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