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Elevated intracellular calcium concentrations, in turn, appear to prompt the secretory vesicles inside these cells to release growth hormone into the bloodstream

doi: 10.1007/s00018-004-4189-6 81 CurtinJABusamKPinkelDBastianBC

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All these changes, particularly in the first few weeks of treatment or in the early days of dose adjustment, can leave the body feeling drained while the body adapts