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In PIONEER 8, compared with patients receiving basal or premixed insulin, patients receiving basal-bolus insulin appeared to have a greater duration of diabetes (13 and 14 years vs 16 years, respectively), greater body weight (85 and 78 kg vs 89 kg) and a higher total daily insulin dose (35 and 48 U vs 79 U) (Table 2(ii))

Clinical and Experimental Nephrology , 15 (4), 550555

21 What dose should be used

Together, these findings point to an exciting new frontier one where preserving energy transfer may be as vital as correcting mechanics in inherited hypercontractile cardiomyopathies

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