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Current patch technology cannot reliably deliver therapeutic GLP-1 doses through the skin barrier

Foundational primary-source mechanistic paper for GLP-1R-mediated effects on human adipose stem cells (subcutaneous, from morbidly obese subjects undergoing bariatric surgery): liraglutide at 10 to 100 nM significantly inhibited ASC proliferation and viability (45-50% inhibition at 6 days), reduced glucose uptake dose-dependently, and the effect was reversed by GLP-1R antagonist exendin 9-39, confirming receptor-mediated mechanism

22 news release

To help with both blood sugar and weight loss, I've tried several of these incretin-based medicines

Gearhardt and DiFeliceantonio, 2023