With this new cosmology in mind, I sat down with Peter Attias book, Outlive: The Science and Art of Longevity, cowritten with Outside contributing editor Bill Gifford
More interestingly, research has found that using siRNA to knock down the Growth factor independence 1 (Gfi1) gene in chondrocytes, or overexpressing this gene via intra-articular AAV-Gfi1 injection, inactivated the MAPK signaling pathway, subsequently observing downregulation of ferroptosis promoters such as Cox2 and Acsl4 and upregulation of ferroptosis inhibitors such as GPX4 and SLC7A11, ultimately alleviating cartilage degeneration, osteophyte formation, and synovitis, and improving OA progression (Jin et al., 2025)
L-cysteine is classified as a semi-essential amino acid because it can be made in small amounts by the human body, but many people can still benefit from consuming more cysteine from their diets or supplements because of its numerous health benefits
Inflammatory cell infiltration follows tissue injury, initially serving protective functions but potentially causing secondary damage if prolonged or excessive
Thymic peptides restrain the inflammatory response in mice with experimental autoimmune encephalomyelitis
