endogenous glp-1 Glucagon-like peptide-1 receptor: mechanisms and advances in therapy Glucagon, GLP-1 and Thermogenesis

Studi su fibroblasti cutanei umani in coltura hanno documentato la sua capacit di stimolare la sintesi di collagene di tipo I e III, fibronectina e glicosaminoglicani della matrice extracellulare, di aumentare l'attivit delle metalloproteinasi di matrice (MMP) per il rimodellamento del collagene vecchio e danneggiato, e di ridurre contemporaneamente i marcatori dello stress ossidativo intracellulare

The hormone is rapidly degraded in the body, primarily by the enzyme dipeptidyl peptidase-4 (DPP-4), which can complicate the measurement process

J Nutr 133, 2444S2447S

Of note - many patients can not tolerate any provocation especially with glutathione, as the mobilization is too much for the body to properly excrete

Nevertheless, the mechanisms by which peripherally administered DPP4i inhibits enterocyte chylomicron secretion have not been determined