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Endocrinology 7, 507516, doi: 10.1038/nrendo.2011.77 (2011)

Additionally, the loss of muscle mass has been problematic for some individuals taking this class of medication, with lean body mass accounting for up to 1540% of total weight loss

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Insulin sensitivity was assessed by total GDR measured during the hyperinsulinemiceuglycemic clamp in a subgroup of 50 patients [27] and by homeostatic model assessment in all patients [28]