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Triana-Martnez F, Picallos-Rabina P, Da Silva-lvarez S et al (2019) Identification and characterization of cardiac glycosides as senolytic compounds

But the patterns seen were highly consistent with what is already known about the pharmacology and neurobiological mechanisms of the drugs, they concluded

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Data availability All RNA-seq data have been deposited in the GEO and are accessible through GEO Series accession numbers GSE272456 (HCT116) and 810 GSE272391 (AKP organoids) or at RNA-seq data of the clinical cohort have previously been deposited at GSE103479 (ref

These medications bind to GLP-1 receptors located throughout the body, including the pancreas, gastrointestinal tract, and importantly, the central nervous system