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The accumulation of oxidation products (MDA, PC) and depletion of natural cellular antioxidants (TAS, SOD, GPX, and CAT) have been detected in stored canine whole blood, along with increased hemolysis

The reason behind this is that the peptides are unstable and you can run the risk of breaking them making them less effective

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Additionally, it was determined that there was a possibility the observed retinal abnormalities were not caused by acute hyperglycemia but rather the loss of IGF-1 activity in cases of diabetes [4]

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