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Pre-existing Conditions That Increase Risk Some health conditions may make people more prone to developing musculoskeletal discomfort, such as neck pain, when starting semaglutide

It is also prescribed off-label for weight loss in people with obesity or overweight when combined with diet and exercise

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Scirica BM, Bhatt DL, Braunwald E, Steg PG, Davidson J, Hirshberg B, Ohman P, Frederich R, Wiviott SD, Hoffman EB, Cavender MA, Udell JA, Desai NR, Mosenzon O, McGuire DK, Ray KK, Leiter LA, Raz I, Committee S-TS, and Investigators