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In a 2026 trial, adults with alcohol use disorder and obesity taking semaglutide clocked in fewer heavy drinking days than those on placebo
What were once drugs intended for type 2 diabetes, GLP-1 agonists have exploded in popularity due to their secondary function to help lose weight
Recent clinical trials have shown promising results, making it a potent contender among weight loss drugs
Via screening 18 HDACs for the potential delactylase activity, Zhao and colleagues reported that HDAC1-3 and SIRT1-3 could cleave L-lactyllysine marks in vitro [95], especially for nuclear HDAC1-3 serving as the most robust delactylases, suggesting a critical role of HDAC1-3 for the removal of histone lactylation [95]
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