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The combined use of these medications was first reported in 2014 [61], and the number of studies has grown exponentially since then

He began his medical career at Middlesex Hospital, UCL, where he was also a Medical Research Council clinical fellow

A 2024 review published in Diabetes, Obesity & Metabolism (cited by Endocrine News, September 2025) put the range at 15% to 60% of total weight lost potentially coming from lean mass - with the spread reflecting real differences in patient age, which drug, and what the person is doing (or not doing) with their nutrition and training