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Relative to rAmy bound to CTR, Cagri is likely to require extra energy to weaken the salt bridge to attain a CT-like state, thus providing a structural rationale for the smaller population of Cagri-bound particles sampling a CT-like conformation

102 ZervoudisS.IatrakisG.PeitsidisP.PeitsidouA.PapandonopolosL.NikolopoulouM

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78 Moreover, many of these findings are based on limiting dilution transplantation in immunodeficient mice, a context lacking the full complexity of the human TME, including immune regulation and niche-derived signals