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The characteristics of included studies are outlined in Tables 2 and 3

GLP-1 RA medications used in this patient population significantly lowered the risk of atrial fibrillation-related events for patients with diabetes, atrial fibrillation (AF), and obesity, with a particular benefit observed for those with severe obesity (TRANSFORM-AF study, Heart Rhythm 2025

Nausea was the most frequent effect at 43.9% versus 16.1%

By simultaneously aiming at GLP-1, GIP, and glucagon receptors, these drugs, such as retatrutide, deliver significantly greater efficacy than current therapies, expanding the addressable patient base