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Cardiac hypertrophy leads to heart failure at the later decompensated stage of the disease process, which is a primary cause of morbidity and mortality

However, emerging data and mechanistic plausibility suggest that certain populations may be at higher risk of suboptimal intake or depletion, particularly with prolonged therapy, rapid weight loss, restricted dietary variety or pre-existing marginal nutrient status

This study suggests that GLP-1RAs could be promising new therapeutic agents for obese asthma patients, particularly due to their impact on the expression of IL-1 modulated by nucleotide oligomerization domain-like receptor protein 3 (NLRP3) [249]

In December 2024, a phase IIa dose-ranging trial (NCT06717425 ) to investigate this drug began, and is due to end in December 2025 5