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Sulforaphane (54) is a potent inducer of the Nrf2 transcription factor, has excellent blood brain barrier penetration (55), and might expand the size of the glutathione reservoir by increasing expression of GCL, the rate liming step in glutathione biogenesis

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N Engl J Med 384(11):9891002 [DOI] [PubMed] [Google Scholar] 22.Wilding JPHBR, Calanna S, Van Gaal LF, McGowan BM, Rosenstock J, Tran MTD, Wharton S, Yokote K, Zeuthen N, Kushner RF (2021) Impact of semaglutide on body composition in adults with overweight or obesity: exploratory analysis of the STEP 1 study