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SGLT2 inhibitors were chosen as the comparator given they are guideline-recommended second-line glucose-lowering medication and share similar cardiovascular benefits with GLP-1RA, which helps reduce confounding by indication

Potential claims generally involve medications containing the active ingredient semaglutide or tirzepatide, including Ozempic, Wegovy, Rybelsus, Mounjaro, and Zepbound

The subunit is encoded by the IDH3A gene which is located on chromosome 15q25.1 and is composed of 12 exons that encode a precursor protein of 366 amino acids

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The isolated pancreata were placed into 15 mL conical tubes containing 10 mL of 0.23 mg/mL liberase and incubated at 37 C for 30 min